301 Gene expression and genetic mutation contributing to variety of basal cell carcinoma

Basal cell carcinoma (BCC) has a variety of clinical and histological divergence. For instance, morpheaform BCC is rare subtype with poor prognosis. BCCs in Asian people can be diagnosed based on the characteristic pigment features through dermoscopy, while Caucasian usually lack pigmentation, which often make diagnosis more difficult. Trichoblastoma benign tumor, although it closely resembles to dermoscopy features. Factors that contribute diversity have not yet been known. We surveyed distinction among BCC, trichoblastoma, common also variances between nonpigmented pigmented from viewpoint gene expression genetic mutations. Transcriptomic analysis was performed 6 cases nodular 3 trichoblastoma. In addition, exome 5 (3 Japanese, 2 Caucasian) Compared type BCCs, genes belonging MAGE PRAME families were frequently expressed BCCs. Particularly MAGE-A2 strongly skin lesion observed by immunohistochemical study. Genes related hemoglobin blood coagulation fibrinolytic system including HBG1, FGA, APOH highly BCC. CGB5, encoding gonadotropin, one specifically commonly trichoblastomas. isoforms are aberrantly wide human cancers, each development maintenance cancer cells, metastasis invasion, respectively. High might key its invasive local destruction